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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tiparp
Name: TCDD-inducible poly(ADP-ribose) polymerase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tiparpaffects expressionISOTIPARP (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of TIPARP mRNAPMID:21714911
Tiparpaffects methylationISOTIPARP (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of TIPARP 5' UTRPMID:27901495
Tiparpincreases expressionISOTIPARP (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of TIPARP mRNAPMID:20064835 PMID:20106945 PMID:21802500 PMID:21887816 PMID:22178795 PMID:24472612 PMID:30453624
Tiparpincreases expressionISOTiparp (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in increased expression of TIPARP mRNA; Benzo(a)pyrene results in increased expression of TIPARP mRNAPMID:19770486 PMID:20713471 PMID:21569818 PMID:21715664 PMID:21995607 PMID:32553695
Tiparpincreases methylationISOTIPARP (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of TIPARP promoterPMID:27901495
Tiparpmultiple interactionsISOTiparp (Mus musculus)6480464CTD[Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of TIPARP mRNA; AHR affects the reaction [Benzo(a)pyrene results in increased expression of TIPARP mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to TIPARP promoter]PMID:21995607 PMID:32553695
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