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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppm1d
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1D
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppm1daffects expressionISOPPM1D (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of PPM1D mRNAPMID:21873647
Ppm1dincreases expressionISOPPM1D (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PPM1D mRNA; Benzo(a)pyrene results in increased expression of PPM1D proteinPMID:20106945 PMID:21632981 PMID:22316170 PMID:22409540 PMID:32234424
Ppm1dincreases expressionISOPpm1d (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in increased expression of PPM1D mRNA; Benzo(a)pyrene results in increased expression of PPM1D mRNAPMID:19770486 PMID:32553695
Ppm1dmultiple interactionsISOPpm1d (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PPM1D mRNA]PMID:22228805
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