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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ube4b
Name: ubiquitination factor E4B
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ube4baffects methylationISORGD:13123556480464CTDBenzo(a)pyrene affects the methylation of UBE4B intron

PMID:30157460
Ube4bdecreases expressionISORGD:13123556480464CTDBenzo(a)pyrene results in decreased expression of UBE4B mRNA

PMID:26238291
Ube4bincreases mutagenesisISORGD:13123556480464CTDBenzo(a)pyrene results in increased mutagenesis of UBE4B gene

PMID:25435355
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.