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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304724
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox21
Name: SRY-box transcription factor 21
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox21affects methylationISOSOX21 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SOX21 exonPMID:27901495
Sox21decreases expressionISOSOX21 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SOX21 mRNAPMID:22316170
Sox21decreases expressionISOSox21 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SOX21 mRNAPMID:27195522
Sox21increases methylationISOSOX21 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SOX21 promoterPMID:27901495
Sox21multiple interactionsISOSox21 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SOX21 mRNA]PMID:22228805
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