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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304702
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Colgalt2decreases expressionISOColgalt2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of COLGALT2 mRNAPMID:22228805
Colgalt2decreases expressionISOCOLGALT2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of COLGALT2 mRNAPMID:20106945 PMID:21632981
Colgalt2decreases methylationISOCOLGALT2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of COLGALT2 promoterPMID:27901495
Colgalt2increases expressionISOColgalt2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of COLGALT2 mRNAPMID:32417428
Colgalt2increases methylationISOCOLGALT2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of COLGALT2 5' UTR; Benzo(a)pyrene results in increased methylation of COLGALT2 exonPMID:27901495
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