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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303187
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Phactr1
Name: phosphatase and actin regulator 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationISORGD:13531736480464CTDBenzo(a)pyrene affects the methylation of PHACTR1 intron

PMID:30157460
increases expressionISORGD:16157026480464CTDBenzo(a)pyrene results in increased expression of PHACTR1 mRNA

PMID:22228805
increases mutagenesisISORGD:13531736480464CTDBenzo(a)pyrene results in increased mutagenesis of PHACTR1 gene

PMID:25435355
multiple interactionsISORGD:16157026480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PHACTR1 mRNA]

PMID:22228805
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.