Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11340
Species: Mus musculus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of SPP1 mRNAPMID:19770486
Spp1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of SPP1 mRNAPMID:21569818 PMID:22228805
Spp1affects methylationISOSPP1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SPP1 promoterPMID:27901495
Spp1increases expressionISOSPP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of SPP1 mRNAPMID:16269432 PMID:22316170 PMID:26238291
Spp1multiple interactionsISOSpp1 (Rattus norvegicus)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SPP1 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SPP1 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SPP1 mRNAPMID:18711122
Spp1multiple interactionsISOSPP1 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SPP1 mRNA; [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SPP1 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SPP1 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SPP1 mRNAPMID:17690111
Go Back to source page   Continue to Ontology report