GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rb1 | decreases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of RB1 mRNA | PMID:22228805 | Rb1 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of RB1 mRNA | PMID:19770486 PMID:22228805 | Rb1 | multiple interactions | EXP | | 6480464 | CTD | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of RB1 mRNA] | PMID:22228805 | Rb1 | affects methylation | ISO | RB1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of RB1 intron; Benzo(a)pyrene affects the methylation of RB1 promoter | PMID:27901495 PMID:30157460 | Rb1 | decreases expression | ISO | Rb1 (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of RB1 mRNA; Benzo(a)pyrene results in decreased expression of RB1 protein | PMID:19408242 PMID:20064080 | Rb1 | increases expression | ISO | Rb1 (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of RB1 protein | PMID:19408242 PMID:21467743 | Rb1 | increases expression | ISO | RB1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of RB1 mRNA; Benzo(a)pyrene results in increased expression of RB1 protein; Benzo(a)pyrene results in increased expression of RB1 protein modified form | PMID:20850422 PMID:33411230 | Rb1 | increases phosphorylation | ISO | Rb1 (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene results in increased phosphorylation of RB1 protein | PMID:17141280 | Rb1 | multiple interactions | ISO | Rb1 (Rattus norvegicus) | 6480464 | CTD | [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of RB1 mRNA; [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of RB1 protein; AHR affects the reaction [Benzo(a)pyrene results in increased phosphorylation of RB1 protein]; Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in decreased expression of RB1 mRNA]; Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in decreased expression of RB1 protein] | PMID:17141280 PMID:19408242 PMID:20064080 | | ||||||||||||||||||||||
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