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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11121
Species: Mus musculus
RGD Object: Gene
Symbol: Plk1
Name: polo like kinase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plk1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of PLK1 mRNAPMID:32417428
Plk1decreases expressionISOPLK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PLK1 mRNA; Benzo(a)pyrene results in decreased expression of PLK1 proteinPMID:20064835 PMID:20106945 PMID:21632981 PMID:22316170 PMID:29126329 PMID:32234424 PMID:32717239
Plk1decreases methylationISOPLK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PLK1 exonPMID:27901495
Plk1increases methylationISOPLK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PLK1 promoterPMID:27901495
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