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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11065
Species: Mus musculus
RGD Object: Gene
Symbol: Pde4b
Name: phosphodiesterase 4B, cAMP specific
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pde4bdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of PDE4B mRNAPMID:21569818
Pde4baffects methylationISOPDE4B (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PDE4B 5' UTR; Benzo(a)pyrene affects the methylation of PDE4B promoterPMID:27901495
Pde4bdecreases expressionISOPDE4B (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PDE4B mRNAPMID:35870112
Pde4bincreases expressionISOPDE4B (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PDE4B mRNAPMID:22316170
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