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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10983
Species: Mus musculus
RGD Object: Gene
Symbol: Ngfr
Name: nerve growth factor receptor (TNFR superfamily, member 16)
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ngfrincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of NGFR mRNA; Benzo(a)pyrene results in increased expression of TNFRSF10B mRNAPMID:15034205 PMID:19770486 PMID:21964900 PMID:22228805 PMID:22610609 PMID:32417428
Ngfrmultiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TNFRSF10B mRNA; AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of TNFRSF10B mRNA]PMID:15034205 PMID:27858113
Ngfraffects methylationISONGFR (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of NGFR 3' UTRPMID:27901495
Ngfrdecreases expressionISONgfr (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of NGFR mRNAPMID:21839799
Ngfrdecreases expressionISONGFR (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of NGFR mRNAPMID:20106945
Ngfrincreases expressionISONGFR (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of NGFR mRNAPMID:32234424 PMID:35870112
Ngfrincreases methylationISONGFR (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of NGFR promoterPMID:27901495
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