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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10947
Species: Mus musculus
RGD Object: Gene
Symbol: Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Myh11increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of MYH11 mRNAPMID:22228805
Myh11affects methylationISOMYH11 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of MYH11 3' UTRPMID:30157460
Myh11decreases expressionISOMYH11 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of MYH11 proteinPMID:24431215
Myh11increases methylationISOMYH11 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of MYH11 5' UTR; Benzo(a)pyrene results in increased methylation of MYH11 exonPMID:27901495
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