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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10803
Species: Mus musculus
RGD Object: Gene
Symbol: Il6ra
Name: interleukin 6 receptor, alpha
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6radecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of IL6RA mRNAPMID:22228805
Il6raincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of IL6RA mRNAPMID:21569818
Il6raaffects expressionISOIL6R (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of IL6R mRNAPMID:21714911
Il6raaffects methylationISOIL6R (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of IL6R promoterPMID:27901495
Il6radecreases expressionISOIL6R (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of IL6R mRNAPMID:32234424
Il6raincreases expressionISOIL6R (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of IL6R mRNAPMID:21632981 PMID:21871943 PMID:26238291
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