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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10789
Species: Mus musculus
RGD Object: Gene
Symbol: Il1a
Name: interleukin 1 alpha
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1aincreases expression ISOIL1A (Homo sapiens)152975620RGDbenzo[a]pyrene increases expression of IL1A mRNA in lung epithelial cell 
Il1aincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of IL1A mRNAPMID:32417428
Il1aincreases expressionISOIL1A (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of IL1A mRNAPMID:16002475 PMID:17879257 PMID:19152381 PMID:20064835 PMID:20464547 PMID:22178795 PMID:28351761 PMID:35870112
Il1amultiple interactionsISOIL1A (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1A mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1A mRNA]; chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1A mRNA]PMID:19152381 PMID:20464547
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