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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of EGF mRNA

PMID:22228805
multiple interactionsEXP 6480464CTDAHR protein affects the reaction [Benzo(a)pyrene inhibits the reaction [EGF protein binds to EGFR protein]], Benzo(a)pyrene inhibits the reaction [EGF protein binds to EGFR protein]

PMID:6309801
multiple interactionsISORGD:25426480464CTDEGF protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA], EGF protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]

PMID:25233930
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.