Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10265
Species: Mus musculus
RGD Object: Gene
Symbol: Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of CACNA1A mRNA

PMID:22228805
multiple interactionsEXP 6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CACNA1A mRNA]

PMID:22228805
affects methylationISORGD:7359506480464CTDBenzo(a)pyrene affects the methylation of CACNA1A intron

PMID:30157460
increases mutagenesisISORGD:7359506480464CTDBenzo(a)pyrene results in increased mutagenesis of CACNA1A gene

PMID:25435355
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.