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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10179
Species: Mus musculus
RGD Object: Gene
Symbol: Apoc3
Name: apolipoprotein C-III
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoc3decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of APOC3 mRNAPMID:19770486 PMID:22228805
Apoc3affects methylationISOAPOC3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of APOC3 promoterPMID:27901495
Apoc3decreases expressionISOAPOC3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of APOC3 mRNA; Benzo(a)pyrene results in decreased expression of APOC3 proteinPMID:21632981 PMID:22316170 PMID:26238291 PMID:32234424 PMID:33278487
Apoc3multiple interactionsISOAPOC3 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of APOC3 mRNA; [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of APOC3 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of APOC3 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of APOC3 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of APOC3 mRNAPMID:17690111
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