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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:2979
Term: baicalein
Definition: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
Chemical ID: MESH:C006680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDbaicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK1 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]PMID:20850421 PMID:31811862
Mapk1affects bindingISOMAPK1 (Homo sapiens)6480464CTDbaicalein binds to MAPK1 proteinPMID:38230788
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDbaicalein results in decreased phosphorylation of MAPK1 proteinPMID:33838155
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDbaicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of MAPK1 mRNA]; baicalein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK1 protein]PMID:10718847 PMID:33838155 PMID:38230788
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