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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:2979
Term: baicalein
Definition: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
Chemical ID: MESH:C006680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRaffects response to substanceEXP 6480464CTDAHR protein affects the susceptibility to baicaleinPMID:22820424
AHRincreases expressionEXP 6480464CTDbaicalein results in increased expression of AHR proteinPMID:14644660
AHRmultiple interactionsEXP 6480464CTDAHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; baicalein binds to and results in increased activity of AHR proteinPMID:14644660 PMID:22820424
AHRincreases activityISOAhr (Mus musculus)6480464CTDbaicalein results in increased activity of AHR proteinPMID:17869316
AHRmultiple interactionsISOAhr (Mus musculus)6480464CTDbaicalein binds to and results in increased activity of AHR proteinPMID:14644660
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