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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:104736480464CTDTunicamycin results in increased expression of NQO1 mRNA, Tunicamycin results in increased expression of NQO1 protein

PMID:22959925, PMID:29289645, PMID:30253173
multiple interactionsISORGD:104736480464CTD[PPARD gene mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of NQO1 mRNA, Exenatide inhibits the reaction [Tunicamycin results in increased expression of NQO1 mRNA], NFE2L2 mRNA affects the reaction [Tunicamycin results in increased expression of NQO1 mRNA]

PMID:22959925, PMID:29289645, PMID:30253173
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.