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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDTunicamycin results in increased activity of CASP12 protein

PMID:18477628
multiple interactionsEXP 6480464CTDNicotine inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein]

PMID:18477628
increases activityISORGD:13480776480464CTDTunicamycin results in increased activity of CASP12 protein

PMID:24224909
increases cleavageISORGD:7314426480464CTDTunicamycin results in increased cleavage of CASP12 protein

PMID:17003819
multiple interactionsISORGD:13480776480464CTDresveratrol inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein]

PMID:24224909
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.