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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90b1
Name: heat shock protein 90 beta family member 1
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90b1increases expressionEXP 6480464CTDTunicamycin results in increased expression of HSP90B1 mRNA; Tunicamycin results in increased expression of HSP90B1 proteinPMID:15049342 PMID:17416481 PMID:20071420 PMID:28399139
Hsp90b1multiple interactionsEXP 6480464CTDibutilide inhibits the reaction [Tunicamycin results in increased expression of HSP90B1 mRNA]PMID:28399139
Hsp90b1increases expressionISOHSP90B1 (Homo sapiens)6480464CTDTunicamycin results in increased expression of HSP90B1 mRNA; Tunicamycin results in increased expression of HSP90B1 proteinPMID:15049342 PMID:17416481 PMID:22378314 PMID:29453283 PMID:33545341 PMID:36586010
Hsp90b1increases expressionISOHsp90b1 (Mus musculus)6480464CTDTunicamycin results in increased expression of HSP90B1 proteinPMID:20477944
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