GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304659
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13122266480464CTDTunicamycin results in increased expression of ARHGEF2 mRNA

Tunicamycin results in increased expression of ARHGEF2 protein

PMID:22378314, PMID:29453283
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.