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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:29693
Term: thiostrepton
Definition: A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent.
Chemical ID: MESH:D013883
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:685566480464CTDThiostrepton results in decreased expression of CCND1 mRNA

PMID:22321511
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.