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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:29681
Term: surfactin
Definition: Any mixture comprising isoforms of a bacterial cyclic lipopeptide antibiotic produced by various strains of Bacillus subtilis. The isoforms are cyclodepsipeptides containing at least seven amino acid residues. Among the most effective biosurfactants, surfactin can reduce the surface tension of water from 72 to 27 mN/m at a concentration as low as 0.005%.
Chemical ID: MESH:C009365
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDsurfactin peptide results in decreased expression of BCL2 proteinPMID:19954742 PMID:34850538
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]PMID:19954742
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