GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sqstm1 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of SQSTM1 mRNA; sodium arsenite results in increased expression of SQSTM1 protein; sodium arsenite results in increased expression of SQSTM1 protein alternative form; sodium arsenite results in increased expression of SQSTM1 protein modified form | PMID:11525245 PMID:12745069 PMID:16014739 PMID:25270620 PMID:26483381 PMID:26631322 PMID:28125038 PMID:36557995 | Sqstm1 | multiple interactions | EXP | | 6480464 | CTD | ATG7 gene mutant form inhibits the reaction [sodium arsenite results in increased degradation of SQSTM1 protein]; Estrogens promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; SOCS3 mutant form inhibits the reaction [Estrogens promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]; sodium arsenite promotes the reaction [SQSTM1 protein binds to KEAP1 protein]; sodium arsenite results in increased expression of and results in increased degradation of SQSTM1 protein; sodium arsenite results in increased expression of and results in increased ubiquitination of SQSTM1 protein; SQSTM1 protein affects the reaction [sodium arsenite results in decreased expression of FABP4 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in decreased expression of S100A6 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in decreased expression of S100A9 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in decreased expression of SLC10A2 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in decreased expression of UGT2B37 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of ACAA1B mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CAR3 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CES1D mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CES1F mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CES1G mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CYP1A2 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CYP2A5 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CYP2C37 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CYP2C50 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of GCLC mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of GSTA3 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of GSTM1 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of USP2 mRNA] | PMID:26483381 PMID:26631322 PMID:28359760 PMID:33933676 | Sqstm1 | affects expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | sodium arsenite affects the expression of SQSTM1 protein | PMID:34861471 | Sqstm1 | decreases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in decreased expression of SQSTM1 mRNA; sodium arsenite results in decreased expression of SQSTM1 protein | PMID:34032870 PMID:35750204 | Sqstm1 | increases expression | ISO | Sqstm1 (Rattus norvegicus) | 6480464 | CTD | sodium arsenite results in increased expression of SQSTM1 protein | PMID:30551535 | Sqstm1 | increases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of SQSTM1 mRNA; sodium arsenite results in increased expression of SQSTM1 protein | PMID:24516582 PMID:25493608 PMID:26535918 PMID:27413109 PMID:28125038 PMID:28229933 PMID:28888487 PMID:29301061 PMID:34758851 PMID:36586010 PMID:36958258 | Sqstm1 | increases response to substance | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | SQSTM1 protein results in increased susceptibility to sodium arsenite | PMID:23589329 | Sqstm1 | multiple interactions | ISO | Sqstm1 (Rattus norvegicus) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [Sodium Fluoride results in increased abundance of Fluorides]] results in increased expression of SQSTM1 mRNA; [[sodium arsenite results in increased abundance of Arsenic] co-treated with [Sodium Fluoride results in increased abundance of Fluorides]] results in increased expression of SQSTM1 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SQSTM1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SQSTM1 protein | PMID:31844926 | Sqstm1 | multiple interactions | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SQSTM1 protein; [sodium arsenite results in increased abundance of arsenite] inhibits the reaction [Cycloheximide results in decreased expression of SQSTM1 protein]; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of SQSTM1 mRNA; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of SQSTM1 protein; Acetylcysteine affects the reaction [sodium arsenite affects the expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of SQSTM1 mRNA]; NFE2L2 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of SQSTM1 mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; pyrazolanthrone affects the reaction [sodium arsenite affects the expression of SQSTM1 protein]; SB 203580 inhibits the reaction [sodium arsenite affects the expression of SQSTM1 protein]; sodium arsenite promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; sodium arsenite promotes the reaction [GSDMD protein binds to SQSTM1 protein]; sodium arsenite promotes the reaction [SQSTM1 protein binds to SNAI1 protein]; sodium arsenite results in increased expression of and affects the localization of SQSTM1 protein; sodium arsenite results in increased expression of and affects the splicing of SQSTM1 mRNA; sodium arsenite results in increased expression of and results in increased phosphorylation of SQSTM1 protein; sodium arsenite results in increased expression of and results in increased ubiquitination of SQSTM1 protein; SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA]; SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of NFE2L2 protein]; SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of NQO1 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in decreased expression of CDH1 protein]; SQSTM1 protein affects the reaction [sodium arsenite results in increased cleavage of BAX protein]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of and results in increased lipidation of MAP1LC3B protein]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of BNIP3L protein]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of SNAI1 protein]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of VIM protein]; SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of and results in increased activity of NFE2L2 protein]; SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of GCLC mRNA]; SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA]; sulforaphane inhibits the reaction [sodium arsenite affects the localization of SQSTM1 protein] | PMID:23589329 PMID:25879800 PMID:28125038 PMID:28229933 PMID:28359760 PMID:28888487 PMID:31781319 PMID:32076005 PMID:32645460 PMID:34758851 PMID:34861471 PMID:34920032 PMID:36958258 | | ||||||||||||||||||||||
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