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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736368
Species: Mus musculus
RGD Object: Gene
Symbol: Pdx1
Name: pancreatic and duodenal homeobox 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdx1multiple interactionsEXP 6480464CTD[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein; SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]PMID:11574405
Pdx1affects localizationISOPDX1 (Homo sapiens)6480464CTDsodium arsenite affects the localization of PDX1 proteinPMID:9873045
Pdx1decreases expressionISOPdx1 (Rattus norvegicus)6480464CTDsodium arsenite results in decreased expression of PDX1 mRNAPMID:32531573
Pdx1multiple interactionsISOPdx1 (Rattus norvegicus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PDX1 mRNA; Zinc deficiency affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PDX1 mRNA]PMID:31542844
Pdx1multiple interactionsISOPDX1 (Homo sapiens)6480464CTD[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein; SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [sodium arsenite affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of PDX1 protein]; sodium arsenite results in increased phosphorylation of and results in increased activity of PDX1 proteinPMID:11574405 PMID:9873045
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