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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736157
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCA1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCA1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of ABCA1 mRNA; sodium arsenite results in decreased expression of ABCA1 proteinPMID:31150806
ABCA1increases methylationEXP 6480464CTDsodium arsenite results in increased methylation of ABCA1 promoterPMID:31150806
ABCA1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased methylation of ABCA1 promoter]; Decitabine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 mRNA]; Decitabine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 protein]PMID:31150806
ABCA1decreases expressionISOAbca1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of ABCA1; sodium arsenite results in decreased expression of ABCA1 mRNAPMID:21512104 PMID:25367288
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