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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2decreases activityEXP 6480464CTDsodium arsenite results in decreased activity of CYP1A2 proteinPMID:11162773
CYP1A2decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of CYP1A2; sodium arsenite results in decreased expression of CYP1A2 mRNAPMID:23052196 PMID:29301061 PMID:32844245
CYP1A2increases methylationEXP 6480464CTDsodium arsenite results in increased methylation of CYP1A2 intronPMID:32844245
CYP1A2multiple interactionsEXP 6480464CTD[Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP1A2 mRNA; sodium arsenite inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A2 mRNA]; sodium arsenite inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A2 protein]; sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; tin mesoporphyrin inhibits the reaction [sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]]PMID:11162773 PMID:20188822 PMID:35747940
CYP1A2decreases expressionISOCyp1a2 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of CYP1A2 mRNAPMID:17451858 PMID:25065748
CYP1A2increases expressionISOCyp1a2 (Mus musculus)6480464CTDsodium arsenite results in increased expression of CYP1A2 mRNA; sodium arsenite results in increased expression of CYP1A2 proteinPMID:22535251 PMID:29044176 PMID:33933676
CYP1A2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP1A2 mRNA]; sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of CYP1A2 mRNA]PMID:22535251 PMID:33933676 PMID:36893905
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