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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733638
Species: Homo sapiens
RGD Object: Gene
Symbol: GATA3
Name: GATA binding protein 3
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GATA3affects methylationEXP 6480464CTDsodium arsenite affects the methylation of GATA3 genePMID:28589171
GATA3decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of GATA3 mRNA; sodium arsenite results in decreased expression of GATA3 proteinPMID:12634122 PMID:25493608 PMID:37269932
GATA3increases stabilityEXP 6480464CTDsodium arsenite results in increased stability of GATA3 mRNAPMID:25493608
GATA3multiple interactionsEXP 6480464CTDGATA3 protein inhibits the reaction [sodium arsenite results in increased expression of CDH1 mRNA]; GATA3 protein inhibits the reaction [sodium arsenite results in increased expression of FOXA1 mRNA]PMID:37269932
GATA3decreases expressionISOGata3 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of GATA3 mRNAPMID:36209798
GATA3increases expressionISOGata3 (Mus musculus)6480464CTDsodium arsenite results in increased expression of GATA3 mRNAPMID:28843991 PMID:36435854
GATA3multiple interactionsISOGata3 (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of GATA3 mRNAPMID:30889423 PMID:33148380
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