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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of CDKN1A mRNAPMID:11812925 PMID:33933676
Cdkn1aincreases activityEXP 6480464CTDsodium arsenite results in increased activity of CDKN1A proteinPMID:11807808
Cdkn1aincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of CDKN1A mRNA; sodium arsenite results in increased expression of CDKN1A proteinPMID:11807808 PMID:16166651 PMID:18996350 PMID:20477944 PMID:20883709 PMID:23143138 PMID:23890198 PMID:25787150 PMID:27723467 PMID:30278210 PMID:36209798
Cdkn1amultiple interactionsEXP 6480464CTDPlant Extracts inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; sodium arsenite promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; TRP73 protein affects the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]PMID:11807808 PMID:20477944 PMID:27723467
Cdkn1aaffects expressionISOCDKN1A (Homo sapiens)6480464CTDsodium arsenite affects the expression of CDKN1A proteinPMID:30123091
Cdkn1aaffects response to substanceISOCDKN1A (Homo sapiens)6480464CTDCDKN1A protein affects the susceptibility to sodium arsenitePMID:20000476
Cdkn1adecreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDsodium arsenite results in decreased expression of CDKN1A mRNA; sodium arsenite results in decreased expression of CDKN1A proteinPMID:16876216
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of CDKN1A mRNA; sodium arsenite results in decreased expression of CDKN1A proteinPMID:20036271
Cdkn1aincreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDsodium arsenite results in increased expression of CDKN1A proteinPMID:16797887
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDsodium arsenite results in increased expression of CDKN1A mRNA; sodium arsenite results in increased expression of CDKN1A proteinPMID:10910055 PMID:11507245 PMID:11813266 PMID:12208374 PMID:12377979 PMID:12760830 PMID:15734884 PMID:16614167 PMID:20375080 PMID:21642427 PMID:22354777 PMID:24816914 PMID:25199682 PMID:26091798 PMID:28125038 PMID:29039521 PMID:30460075 PMID:32890875 PMID:36089002 PMID:36958258
Cdkn1aincreases phosphorylationISOCDKN1A (Homo sapiens)6480464CTDsodium arsenite results in increased phosphorylation of CDKN1A proteinPMID:28586017
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CDKN1A mRNA; [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of CDKN1A mRNA; [sodium arsenite co-treated with tetrandrine] affects the expression of CDKN1A protein; [sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1A protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDKN1A mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDKN1A protein; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; ATM gene mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDKN1A mRNA]; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDKN1A protein]; EGFR mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; ELK1 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; ERBB2 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; GPX4 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; Lapatinib inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; MAP2K1 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; MAP2K4 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; MAP2K7 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; MAPK1 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; sodium arsenite promotes the reaction [CDK4 protein binds to CDKN1A protein]; sodium arsenite promotes the reaction [CDK6 protein binds to CDKN1A protein]; sodium arsenite promotes the reaction [ELK1 protein binds to CDKN1A promoter]; SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; tyrphostin AG825 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; U 0126 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]PMID:11507245 PMID:12208374 PMID:12634122 PMID:15734884 PMID:19082730 PMID:21642427 PMID:23192986 PMID:28125038 PMID:29039521 PMID:30123091 PMID:32890875 PMID:36504884
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