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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732775
Species: Homo sapiens
RGD Object: Gene
Symbol: ALOX5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ALOX5decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of ALOX5 mRNAPMID:34032870
ALOX5multiple interactionsEXP 6480464CTD[sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; SB 203580 inhibits the reaction [sodium arsenite results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of ALOX5 protein]; sodium arsenite results in increased phosphorylation of and results in increased activity of ALOX5 proteinPMID:10779545
ALOX5decreases expressionISOAlox5 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of ALOX5 mRNAPMID:37682722
ALOX5increases expressionISOAlox5 (Mus musculus)6480464CTDsodium arsenite results in increased expression of ALOX5 mRNAPMID:25065748
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