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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69114
Species: Mus musculus
RGD Object: Gene
Symbol: Pdk4
Name: pyruvate dehydrogenase kinase, isoenzyme 4
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdk4decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of PDK4 mRNAPMID:31170414
Pdk4multiple interactionsEXP 6480464CTDsodium arsenite inhibits the reaction [BRD4770 results in increased expression of PDK4 mRNA]; sodium arsenite inhibits the reaction [BRD4770 results in increased expression of PDK4 protein]; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of CCNA2 protein]; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of CCNE1 protein]; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of E2F1 protein]; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of PCNA protein]PMID:27217333 PMID:28003426
Pdk4decreases expressionISOPDK4 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of PDK4 mRNA; sodium arsenite results in decreased expression of PDK4 proteinPMID:27217333 PMID:29301061 PMID:34032870
Pdk4increases expressionISOPDK4 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of PDK4 mRNAPMID:23648393
Pdk4multiple interactionsISOPDK4 (Homo sapiens)6480464CTDBRD4770 inhibits the reaction [sodium arsenite promotes the reaction [EHMT2 protein binds to PDK4 promoter]]; sodium arsenite inhibits the reaction [BRD4770 results in increased expression of PDK4 mRNA]; sodium arsenite inhibits the reaction [BRD4770 results in increased expression of PDK4 protein]; sodium arsenite promotes the reaction [EHMT2 protein binds to PDK4 promoter]PMID:27217333
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