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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62089
Species: Mus musculus
RGD Object: Gene
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prknincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of PRKN mRNA; sodium arsenite results in increased expression of PRKN proteinPMID:36557995
Prknaffects methylationISOPRKN (Homo sapiens)6480464CTDsodium arsenite affects the methylation of PRKN genePMID:28589171
Prkndecreases expressionISOPrkn (Rattus norvegicus)6480464CTDsodium arsenite results in decreased expression of PRKN proteinPMID:30551535
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