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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620721
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Blvra
Name: biliverdin reductase A
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Blvraaffects response to substanceISOBLVRA (Homo sapiens)6480464CTDBLVRA protein affects the susceptibility to sodium arsenitePMID:15741166
Blvramultiple interactionsISOBLVRA (Homo sapiens)6480464CTDBLVRA protein affects the reaction [sodium arsenite results in increased expression of HMOX1 protein]; BLVRA protein affects the reaction [sodium arsenite results in increased expression of JUN mRNA]; BLVRA protein inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; BLVRA protein inhibits the reaction [sodium arsenite results in increased expression of CYCS protein]; BLVRA protein inhibits the reaction [sodium arsenite results in increased expression of TNFRSF10B mRNA]; BLVRA protein inhibits the reaction [sodium arsenite results in increased expression of TNFSF10 protein]; sodium arsenite results in increased phosphorylation of and results in increased activity of BLVRA proteinPMID:15741166
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