GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Shc1 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of SHC1 mRNA | PMID:33360347 | Shc1 | increases phosphorylation | EXP | | 6480464 | CTD | sodium arsenite results in increased phosphorylation of SHC1 protein | PMID:9710602 | Shc1 | multiple interactions | EXP | | 6480464 | CTD | [sodium arsenite results in increased phosphorylation of SHC1 protein] promotes the reaction [SHC1 protein modified form binds to GRB2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein]; EGF protein inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein]; RTKI cpd inhibits the reaction [sodium arsenite promotes the reaction [SHC1 protein modified form binds to EGFR protein binds to GRB protein]]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein]; sodium arsenite promotes the reaction [SHC1 protein modified form binds to EGFR protein binds to GRB protein]; sodium arsenite promotes the reaction [SHC1 protein modified form binds to GRB2 protein]; sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein; Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein] | PMID:33360347 PMID:9710602 | Shc1 | increases expression | ISO | SHC1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of SHC1 mRNA; sodium arsenite results in increased expression of SHC1 protein | PMID:26537450 PMID:33360347 | Shc1 | multiple interactions | ISO | SHC1 (Homo sapiens) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which affects the splicing of SHC1 mRNA; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein]; Folic Acid inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein]; Folic Acid inhibits the reaction [sodium arsenite results in increased expression of SHC1 protein]; SHC1 protein affects the reaction [sodium arsenite results in decreased expression of GDF1 protein]; SHC1 protein inhibits the reaction [sodium arsenite results in decreased expression of GDF1 protein]; SHC1 protein inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]; SHC1 protein inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein]; SIRT1 protein inhibits the reaction [sodium arsenite results in increased expression of SHC1 protein]; sodium arsenite inhibits the reaction [SIRT1 protein binds to SHC1 promoter]; sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein; SP1 protein inhibits the reaction [sodium arsenite results in increased expression of SHC1 protein] | PMID:26537450 PMID:33360347 PMID:35072517 | | ||||||||||||||||||||||
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