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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txnrd1
Name: thioredoxin reductase 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnrd1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of TXNRD1 mRNAPMID:23603382
Txnrd1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of TXNRD1 proteinPMID:29459688
Txnrd1multiple interactionsEXP 6480464CTDSodium Selenite inhibits the reaction [sodium arsenite results in decreased expression of TXNRD1 mRNA]PMID:23603382
Txnrd1decreases expressionISOTXNRD1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of TXNRD1 mRNAPMID:34032870
Txnrd1increases expressionISOTxnrd1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of TXNRD1 mRNAPMID:16014739
Txnrd1increases expressionISOTXNRD1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of TXNRD1 mRNA; sodium arsenite results in increased expression of TXNRD1 proteinPMID:12377979 PMID:12679051 PMID:12760830 PMID:15521073 PMID:20886546 PMID:23876855 PMID:25879800 PMID:26535918 PMID:28229933 PMID:28512695 PMID:28713220 PMID:36586010
Txnrd1multiple interactionsISOTXNRD1 (Homo sapiens)6480464CTD[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of TXNRD1 mRNA; [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of TXNRD1 mRNA; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of TXNRD1 mRNAPMID:23192986 PMID:25873331 PMID:32076005
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