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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319357
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfatc1
Name: nuclear factor of activated T-cells 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfatc1affects expressionISONfatc1 (Mus musculus)6480464CTDsodium arsenite affects the expression of NFATC1 proteinPMID:30742845
Nfatc1affects localizationISONFATC1 (Homo sapiens)6480464CTDsodium arsenite affects the localization of NFATC1 proteinPMID:29528074
Nfatc1increases expressionISONFATC1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of NFATC1 mRNAPMID:29528074
Nfatc1multiple interactionsISONFATC1 (Homo sapiens)6480464CTD[sodium arsenite results in increased abundance of arsenite] which affects the localization of NFATC1 protein; acetovanillone inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which affects the localization of NFATC1 protein]; diphenyleneiodonium inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which affects the localization of NFATC1 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which affects the localization of NFATC1 protein]; sodium arsenite affects the expression of and results in decreased phosphorylation of NFATC1 protein; U 0126 affects the reaction [sodium arsenite affects the expression of NFATC1 protein]PMID:22564430 PMID:29528074
Nfatc1multiple interactionsISONfatc1 (Mus musculus)6480464CTDAcetylcysteine affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; Acetylcysteine affects the reaction [sodium arsenite affects the expression of NFATC1 protein]; NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]; SB 203580 affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; SB 203580 affects the reaction [sodium arsenite affects the expression of NFATC1 protein]PMID:30742845
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