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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1587326
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Polr2a
Name: RNA polymerase II subunit A
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Polr2aincreases phosphorylationISOPOLR2A (Homo sapiens)6480464CTDsodium arsenite results in increased phosphorylation of POLR2A proteinPMID:8126066
Polr2amultiple interactionsISOPOLR2A (Homo sapiens)6480464CTD[Dactinomycin co-treated with sodium arsenite] results in increased phosphorylation of POLR2A protein; sodium arsenite inhibits the reaction [Dichlororibofuranosylbenzimidazole results in decreased phosphorylation of POLR2A protein]; sodium arsenite inhibits the reaction [N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of POLR2A protein]PMID:8126066
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