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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552419
Species: Mus musculus
RGD Object: Gene
Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k6increases expressionISOMAP2K6 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of MAP2K6 mRNAPMID:17879257
Map2k6multiple interactionsISOMAP2K6 (Homo sapiens)6480464CTD[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAP2K6 mRNA; MAP2K6 affects the reaction [sodium arsenite results in increased activity of MAPK1 protein]; MAP2K6 affects the reaction [sodium arsenite results in increased activity of MAPK3 protein]PMID:12634122 PMID:9442025
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