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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332124
Species: Mus musculus
RGD Object: Gene
Symbol: Serpinf1
Name: serine (or cysteine) peptidase inhibitor, clade F, member 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpinf1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of SERPINF1 mRNAPMID:37682722
Serpinf1decreases expressionISOSERPINF1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of SERPINF1 mRNAPMID:29301061 PMID:32844245 PMID:34032870
Serpinf1decreases expressionISOSerpinf1 (Rattus norvegicus)6480464CTDsodium arsenite results in decreased expression of SERPINF1 proteinPMID:29459688 PMID:30408888
Serpinf1increases expressionISOSerpinf1 (Rattus norvegicus)6480464CTDsodium arsenite results in increased expression of SERPINF1 proteinPMID:23229538
Serpinf1increases methylationISOSERPINF1 (Homo sapiens)6480464CTDsodium arsenite results in increased methylation of SERPINF1 exonPMID:32844245
Serpinf1multiple interactionsISOSerpinf1 (Rattus norvegicus)6480464CTD[SERPINF1 protein co-treated with sodium arsenite] results in decreased expression of BCL2 protein; [SERPINF1 protein co-treated with sodium arsenite] results in increased activity of CASP3 protein; [SERPINF1 protein co-treated with sodium arsenite] results in increased activity of CASP9 protein; [SERPINF1 protein co-treated with sodium arsenite] results in increased expression of BAX protein; [SERPINF1 protein co-treated with sodium arsenite] results in increased expression of BBC3 mRNAPMID:30408888
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