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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315695
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1C1
Name: aldo-keto reductase family 1 member C1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1C1affects expressionEXP 6480464CTDsodium arsenite affects the expression of AKR1C1 mRNAPMID:29319823
AKR1C1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of AKR1C1 mRNA; sodium arsenite results in increased expression of AKR1C1 proteinPMID:19696165 PMID:20886546 PMID:25493608 PMID:28595984 PMID:34032870
AKR1C1multiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA; SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA]PMID:31781319
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