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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311629
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dapk1
Name: death associated protein kinase 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13231866480464CTDsodium arsenite results in decreased expression of DAPK1 mRNA, sodium arsenite results in decreased expression of DAPK1 protein

PMID:19577553, PMID:22714537
increases expressionISORGD:13231866480464CTDsodium arsenite results in increased expression of DAPK1 mRNA

PMID:10910055, PMID:24570342
increases methylationISORGD:13231866480464CTDsodium arsenite results in increased methylation of DAPK1 promoter

PMID:17683884, PMID:19577553
multiple interactionsISORGD:13231866480464CTDdecitabine inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein], LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of DAPK1 mRNA], U 0126 inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]

PMID:19577553, PMID:24570342
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.