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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306321
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfap2b
Name: transcription factor AP-2 beta
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfap2bdecreases methylationISOTfap2b (Mus musculus)6480464CTDsodium arsenite results in decreased methylation of TCFAP2B genePMID:32068019
Tfap2bincreases expressionISOTfap2b (Mus musculus)6480464CTDsodium arsenite results in increased expression of TFAP2B mRNAPMID:34968464
Tfap2bmultiple interactionsISOTfap2b (Mus musculus)6480464CTD[sodium arsenite co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of TFAP2B mRNA; Palmitic Acid inhibits the reaction [[sodium arsenite co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of TFAP2B mRNA]; Palmitic Acid promotes the reaction [sodium arsenite results in increased expression of TFAP2B mRNA]; sodium arsenite promotes the reaction [Palmitic Acid results in increased expression of TFAP2B mRNA]PMID:34968464
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