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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10691
Species: Mus musculus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of NR3C1 mRNAPMID:17451858
Nr3c1affects activityISONR3C1 (Homo sapiens)6480464CTDsodium arsenite affects the activity of NR3C1 proteinPMID:17173375
Nr3c1affects methylationISONR3C1 (Homo sapiens)6480464CTDsodium arsenite affects the methylation of NR3C1 genePMID:28589171
Nr3c1decreases activityISONr3c1 (Rattus norvegicus)6480464CTDsodium arsenite results in decreased activity of NR3C1 proteinPMID:11333185
Nr3c1multiple interactionsISONr3c1 (Rattus norvegicus)6480464CTDDithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]; sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]; sodium arsenite inhibits the reaction [NR3C1 protein binds to dexamethasone oxetanone]PMID:1597467 PMID:2226332
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