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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550157
Species: Mus musculus
RGD Object: Gene
Symbol: Kras
Name: Kirsten rat sarcoma viral oncogene homolog
Acc ID: CHEBI:29623
Term: manumycin A
Definition: A polyketide with formula C31H38N2O7 initially isolated from Streptomyces parvulus as a result of a random screening program for farnesyl transferase (FTase) inhibitors. It is a natural product that exhibits anticancer and antibiotic properties.
Chemical ID: MESH:C054474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krasdecreases activityISOKRAS (Homo sapiens)6480464CTDmanumycin results in decreased activity of KRAS proteinPMID:19409983
Krasmultiple interactionsISOKRAS (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [manumycin results in decreased activity of KRAS protein]PMID:19409983
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