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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11215
Species: Mus musculus
RGD Object: Gene
Symbol: Raf1
Name: v-raf-leukemia viral oncogene 1
Acc ID: CHEBI:29623
Term: manumycin A
Definition: A polyketide with formula C31H38N2O7 initially isolated from Streptomyces parvulus as a result of a random screening program for farnesyl transferase (FTase) inhibitors. It is a natural product that exhibits anticancer and antibiotic properties.
Chemical ID: MESH:C054474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1multiple interactionsISORaf1 (Rattus norvegicus)6480464CTDmanumycin inhibits the reaction [Streptozocin results in increased expression of RAF1 protein]; manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]PMID:18569938 PMID:21575692
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