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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730945
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb11
Name: ATP-binding cassette, sub-family B member 11
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases expressionISOAbcb11 (Rattus norvegicus)6480464CTDAzathioprine results in decreased expression of ABCB11 mRNAPMID:27765674
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