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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15decreases expressionISOCXCL8 (Homo sapiens)6480464CTDAzathioprine results in decreased expression of CXCL8 mRNA; Azathioprine results in decreased expression of CXCL8 proteinPMID:19192274
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDAzathioprine results in increased expression of CXCL8 mRNAPMID:22623647
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTDAzathioprine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]PMID:36416909
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