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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2623
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fmr1
Name: fragile X mental retardation 1
Acc ID: CHEBI:29474
Term: (S)-3,5-dihydroxyphenylglycine
Definition: A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.
Chemical ID: MESH:C079215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTD3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA

3,5-dihydroxyphenylglycine affects the localization of FMR1 protein

PMID:15028757
multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]

Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]

Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]

PMID:15028757
multiple interactionsISORGD:7359206480464CTD3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL]

PMID:20393458
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.